MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Author(s): Haowei Li, Zanjing Zhai, Xinhua Qu, Jiake Xu, An Qin*, Kerong Dai*.

Journal Name: Current Drug Targets

Volume 19 , Issue 5 , 2018

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Abstract:

Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.

Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.

Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.

Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

Keywords: Drug targets, miRNAs, osteoclasts, osteolytic diseases, bone homeostasis, biogenesis.

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Article Details

VOLUME: 19
ISSUE: 5
Year: 2018
Page: [422 - 431]
Pages: 10
DOI: 10.2174/1389450117666160502144329
Price: $58

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