Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)Benzofuran-3-one Derivatives

Author(s): Seref Demirayak, Leyla Yurttas, Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun, Ismail Kayagil.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 6 , 2016

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Abstract:

The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4- chlorobenzylidene)-6-[2-(4-methoxyphenyl)-2-oxoethoxy]benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.

Keywords: Antitumor activity, aurone, benzofuranone, chalcone, cytotoxic activity.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [563 - 569]
Pages: 7
DOI: 10.2174/1570180813999160429113316
Price: $58

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