Arginine-rich Cyclic Peptides Enhance Cellular Delivery of Anticancer Agents: Molecular Insights

Author(s): Antara Banerjee, Naser Sayeh, Amir Nasrolahi Shirazi, Rakesh Tiwari, Keykavous Parang, Arpita Yadav.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 7 , 2016

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Abstract:

Research in the area of cancer treatment has undergone a paradigm shift from design of new anticancer agents to efficient drug delivery systems trying to overcome cytotoxicity aspects and bioavailability problems. We have reported earlier two cyclic peptides [WR]4 and [WG(triazole-KRNH2)] 3 for the delivery of phosphopeptides and have considered them for the purpose of enhancing delivery of anticancer drugs. This study attempts to understand at the molecular level self-assembly of cyclic peptides containing tryptophan and arginine residues and their suitability as molecular transporters of anti-HIV and anticancer agents. Ab initio molecular orbital calculations coupled with molecular dynamics simulation studies are reported along with flow cytometry results to show self-assemblage of these cyclic peptides induced by counterions. Our results show the suitability of [WR]4 system in enhancing the delivery of lamivudine and dasatinib in conformity with experimental results. The conformational flexibility, charge environment and HLB of these peptides play an important role in determining their drug delivery capabilities. To our knowledge, this is the first attempt to explain the self-assembly and molecular transporter properties of these systems at the molecular level.

Keywords: Arginine-rich cyclic peptides, dasatinib, molecular dynamics simulations, ab initio, molecular orbital calculations, self assemblage, molecular transporter, tryptophan containing.

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Article Details

VOLUME: 13
ISSUE: 7
Year: 2016
Page: [591 - 604]
Pages: 14
DOI: 10.2174/1570180813999160429113034
Price: $65

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