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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Beyond the Selective Inhibition of Histone Deacetylase 6

Author(s): Daniel A. Rodrigues, Sreekanth Thota and Carlos A.M. Fraga

Volume 16, Issue 14, 2016

Page: [1175 - 1184] Pages: 10

DOI: 10.2174/1389557516666160428115959

Price: $65

Abstract

Histone deacetylase 6 (HDAC6) catalyses the removal of acetyl groups from the lysine residues of a series of non-histone proteins, e.g., α-tubulin, Hsp90 and cortactin. HDAC6 is a unique deacetylase enzyme that is related to various processes that may be important in oncological, immunological and neurological fields, which makes the study of selective inhibitors extremely important to understand the function of this enzyme and to validate HDAC6 as a drug target through the development of clinical candidates. Therefore, this review describes the structure-activity and structureselectivity relationships of HDAC6 inhibitors, which were divided into two main classes, bulky and lipophilic cap groups and inhibitors with phenyl linkers.

Keywords: Histone deacetylase, HDAC6, HDAC6 inhibitor, hydroxamic acids, oncology, selectivity.

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