Background: We report a case of 25 years old male patient with antitubercular drugs
induced exanthematous reaction and hepatotoxicity that was complicated by levofloxacin induced
toxic epidermal necrolysis. The patient was allergic to ciprofloxacin and ofloxacin. Cross reactivity
between ciprofloxacin and levofloxacin might be responsible for causing this reaction.
Conclusion: Issues of cross sensitivity should be kept in mind and the same class of drugs should
strictly be avoided to prevent such complications.
Keywords: Exanthematous reaction, levofloxacin, toxic epidermal necrolysis, antituberculer drugs, cutaneous adverse reaction,
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