Vitamin D deficiency is common in metropolitan cities of India and worldwide due to faulty life
style. The prevalence of vitamin D deficiency has tremendously increased in India despite the fact that it is
located between 8.4° and 37.6° north latitude and majority of the Indian population exposed to ample sunlight
throughout the year. From published data regarding vitamin D deficiency in India estimated prevalence
of vitamin D deficiency is 70%-100% in the adult population. The main identified reason for vitamin D deficiency
is the lack of appropriate sunlight exposure and no consumption (in case of vegetarian population) or
less consumption of vitamin D containing diet (e.g. fish, cod liver oil, beef liver and eggs). Mild to moderate
vitamin D deficiency is identified as a risk factor for type 2 diabetes, due to its protective role against development
of type 2 diabetes mellitus and its complications. Vitamin D may affect glucose homeostasis through
increasing insulin resistance and reducing insulin secretion from beta cells of the pancreas. Vitamin D plays
an important role against oxidative stress, because of its antioxidant property. Till date very few studies determined
the link between vitamin D and oxidative stress in type 2 diabetes mellitus and its complications.
However, more studies are needed to evaluate an underlying mechanism of vitamin D in amelioration of the
oxidative stress in type 2 diabetes mellitus.
Keywords: Glycemic control, insulin resistance, oxidative stress, type 2 diabetes mellitus, vitamin D, vitamin D deficiency.
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