Vitamin D Deficiency and Oxidative Stress in Type 2 Diabetic Population of India

Author(s): Yogita Dhas, Neetu Mishra, Joyita Banerjee.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Volume 14 , Issue 2 , 2016

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Graphical Abstract:


Vitamin D deficiency is common in metropolitan cities of India and worldwide due to faulty life style. The prevalence of vitamin D deficiency has tremendously increased in India despite the fact that it is located between 8.4° and 37.6° north latitude and majority of the Indian population exposed to ample sunlight throughout the year. From published data regarding vitamin D deficiency in India estimated prevalence of vitamin D deficiency is 70%-100% in the adult population. The main identified reason for vitamin D deficiency is the lack of appropriate sunlight exposure and no consumption (in case of vegetarian population) or less consumption of vitamin D containing diet (e.g. fish, cod liver oil, beef liver and eggs). Mild to moderate vitamin D deficiency is identified as a risk factor for type 2 diabetes, due to its protective role against development of type 2 diabetes mellitus and its complications. Vitamin D may affect glucose homeostasis through increasing insulin resistance and reducing insulin secretion from beta cells of the pancreas. Vitamin D plays an important role against oxidative stress, because of its antioxidant property. Till date very few studies determined the link between vitamin D and oxidative stress in type 2 diabetes mellitus and its complications. However, more studies are needed to evaluate an underlying mechanism of vitamin D in amelioration of the oxidative stress in type 2 diabetes mellitus.

Keywords: Glycemic control, insulin resistance, oxidative stress, type 2 diabetes mellitus, vitamin D, vitamin D deficiency.

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Article Details

Year: 2016
Page: [82 - 89]
Pages: 8
DOI: 10.2174/1871525714666160426150233
Price: $58

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PDF: 43