Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread
use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen
with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single
treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful
for clozapine-associated sialorrhea at 87–100 mg per day. We report the effect of very low dose
amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution
of sialorrhea after three days without any emergent adverse effect.
Keywords: Clozapine, amitriptyline, sialorrhea, hypersalivation.
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