Very Low Dose Amitriptyline for Clozapine-Associated Sialorrhea

Author(s): Siddhartha Sinha, Jayati Simlai, Samir K. Praharaj.

Journal Name: Current Drug Safety

Volume 11 , Issue 3 , 2016

Become EABM
Become Reviewer

Abstract:

Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87–100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect.

Keywords: Clozapine, amitriptyline, sialorrhea, hypersalivation.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 11
ISSUE: 3
Year: 2016
Page: [262 - 263]
Pages: 2
DOI: 10.2174/1574886311666160426130252
Price: $65

Article Metrics

PDF: 48
HTML: 2
EPUB: 1
PRC: 1