Current Drug Safety

Dr. Seetal Dodd
University of Melbourne
Geelong, 3220


Very Low Dose Amitriptyline for Clozapine-Associated Sialorrhea

Author(s): Siddhartha Sinha, Jayati Simlai, Samir K. Praharaj.


Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87–100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect.

Keywords: Clozapine, amitriptyline, sialorrhea, hypersalivation.

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Article Details

Year: 2016
Page: [262 - 263]
Pages: 2
DOI: 10.2174/1574886311666160426130252
Price: $58