Introduction: A simple, sensitive and reliable sensor has been explored for the determination
of Melatonin (MEL) using cyclic voltammetry (CV) and square wave voltammetry (SWV).
Method: Irreversible oxidation of MEL was found to proceed through an adsorption controlled pathway
at the glassy carbon electrode. The quantitative estimation of MEL was performed using SWV in a linear
concentration range of 5-200 µM with a sensitivity of 0.0437 µM/ µA and a limit of detection of
0.3432 µM. The proposed protocol was also applied for determining MEL content in pharmaceutical
samples and recovery studies in human urine samples were also performed.
Result: The observed results demonstrated a good agreement with the stated values.
Keywords: Melatonin, glassy carbon electrode, voltammetry, oxidation, human urine.
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