Identification of Degradation Products of Cefoselis Sulfate by HPLC-ESI-Quadrupole Time-Of-Flight-Mass Spectrometry in Aqueous Solutions

Author(s): Przemyslaw Zalewski, Robert Skibinski, Alicja Talaczynska, Magdalena Paczkowska, Judyta Cielecka-Piontek.

Journal Name: Current Pharmaceutical Analysis

Volume 13 , Issue 1 , 2017

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Abstract:

Background: Cefoselis sulfate similarly to other 4th generation cephalosporin is vulnerable for degradation in aqueous solution.

Methods: For identification cefoselis sulfate degradation products chromatographic system consisting of Kinetex, C18, 100A, 100 × 2.1 mm, particle size 5 µm column, mobile phase: acetonitrile – 0.1% formic acid (5:95 V/V) and a hybrid ESI-Q-TOF mass spectrometer was used.

Results: Masses of degradation products with high accuracy (0.09 - 4.64 ppm) were found. Following formulas were obtained: 128.08243 (C5H10N3O), 243.05471 (C8H10N4O3S), 370.06338 (C13H16N5O4S2), 414.05324 (C14H16N5O6S2), 451.13191 (C17H23N8O3S2), 479.12777 (C18H22N8O4S2) and 523.11859 (C19H23N8O6S2) - cefoselis sulfate.

Conclusions: Five previously unknown and one known impurities of CSS were identified by HPLCMS/ MS Degradation pathways of cefoselis sulfate in aqueous solutions were suggested.

Keywords: Cefoselis Sulfate, HPLC, Q-TOF, Degradation in Aqueous Solutions, Identification of Degradation Products.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2017
Page: [26 - 30]
Pages: 5
DOI: 10.2174/1573412912666160422123435
Price: $58

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