Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing,
anti-inflammatory, and antipsychotic activity. These compounds also influence platelet aggregation
and exhibit some other biological activities. Cytokinins are N6-substituted adenines and represent an
important group of phytohormones with diverse biochemical functions in plants, stimulating cell division
and plant growth. The main structural feature of cytokinin nucleosides is the presence of a hydrophobic
hydrocarbon moiety at the N6-position of adenosine. This moiety is responsible for a difference
in physicochemical and biological properties as compared to adenosine. 1-N-Tuberculosinyladenosine
and N6-tuberculosinyladenosine are specifically produced by Mycobacterium tuberculosis as components of the plasmatic
membrane, thus making them attractive targets for clinical test development. Structurally related compounds were found
in marine organisms. It has been shown also that tRNA contains N6-isoprenyladenosine and some other related compounds.
This review summarizes the structural features, biological activity, and the synthesis of cytokinin nucleosides and
some of their closely related derivatives such as cytokinins and terpene derivatives of adenine.
Keywords: Cytokinin nucleosides, Biological activity, Synthesis, N6, tRNA.
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