Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy

Author(s): Richa Goel, Vijay Luxami, Kamaldeep Paul.

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 30 , 2016

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Abstract:

Imidazo[1,2-a]pyridine has been shown to be an important biologically active moiety. This review is a compilation of the scattered output of results of the anticancer activities of the imidazo[1,2-a]pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR, PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[1,2-a]pyridine based analogues have been used as lead molecules and are now under human clinical trials. This review will help the wider scientific community in the area of drug discovery of imidazo[1,2-a]pyridines as novel anticancer agents.

Keywords: Antitubulins, Antitumor, Cyclin dependent kinase inhibitors, Imidazo[1, 2-a]pyridine, Phosphoinositide-3-kinase inhibitors, Topoisomerase-II inhibitors.

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Article Details

VOLUME: 16
ISSUE: 30
Year: 2016
Page: [3590 - 3616]
Pages: 27
DOI: 10.2174/1568026616666160414122644
Price: $58

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