Abstract
The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.
Current Proteomics
Title:Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis
Volume: 13 Issue: 1
Author(s): Jose Antonio O'Daly
Affiliation:
Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.
Abstract: The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
Export Options
About this article
Cite this article as:
O'Daly Antonio Jose, Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis, Current Proteomics 2016; 13 (1) . https://dx.doi.org/10.2174/1570164613666160414115005
DOI https://dx.doi.org/10.2174/1570164613666160414115005 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial [Hot Topic: ABC Transporters in Pharmacology/Physiology and Human Diseases (Guest Editor: Zhe-Sheng (Jason) Chen)]
Current Pharmaceutical Biotechnology Classical Neurotransmitters and Neuropeptides Involved in Parkinson's Disease: Focus on Anti-Parkinsonian Drugs
Current Drug Therapy Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Current Medicinal Chemistry The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson’s Disease in Rats
Current Molecular Pharmacology Novel Approaches Towards Designing of Isoform-Selective Inhibitors Against Class II Histone Deacetylases: The Acute Requirement for Targetted Anticancer Therapy
Current Topics in Medicinal Chemistry BACE1 Levels Correlate with Phospho-Tau Levels in Human Cerebrospinal Fluid
Current Alzheimer Research Mitochondrial Involvement in Psychiatric Illness in Adults
Current Psychiatry Reviews Adenosine and Stroke: Maximizing the Therapeutic Potential of Adenosine as a Prophylactic and Acute Neuroprotectant
Current Neuropharmacology Serotonergic Drugs: Agonists/Antagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer’s Disease
Current Pharmaceutical Design Triheptanoin Supplementation to Ketogenic Diet Curbs Cognitive Impairment in APP/PS1 Mice Used as a Model of Familial Alzheimer’s Disease
Current Alzheimer Research Central Anti-Cholinergic Syndrome Induced by Single Therapeutic Dose of Atropine
Current Drug Safety Zinc-Permeable Ion Channels: Effects on Intracellular Zinc Dynamics and Potential Physiological/Pathophysiological Significance
Current Medicinal Chemistry Diabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review
Current Diabetes Reviews Automated Radiosynthesis and Molecular Docking Studies of Coumarin- Triazole Hybrid with fluorine-18: A feasibility study
Current Radiopharmaceuticals Allosteric Modulators for Adenosine Receptors: An Alternative to the Orthosteric Ligands
Current Topics in Medicinal Chemistry The GABAergic System and the Gastrointestinal Physiopathology
Current Pharmaceutical Design Discovery of New Inhibitors of Urease Enzyme: A Study Using STD-NMR Spectroscopy
Letters in Drug Design & Discovery Diabetes Gene Therapy: Potential and Challenges
Current Gene Therapy Modulation of the TRPV1 Channel: Current Clinical Trials and Recent Patents with Focus on Neurological Conditions
Recent Patents on CNS Drug Discovery (Discontinued) Molecular Mechanisms, Proteinopathies and Therapeutic Strategies in Neurodegenerative Disorders
Current Genomics