Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis

Author(s): Jose Antonio O'Daly .

Journal Name: Current Proteomics

Volume 13 , Issue 1 , 2016

Become EABM
Become Reviewer

Abstract:

The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.

Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 1
Year: 2016
Page: [39 - 47]
Pages: 9
DOI: 10.2174/1570164613666160414115005

Article Metrics

PDF: 20
HTML: 8
EPUB: 2
PRC: 1