Genetic Variation of de novo Lipogenesis Pathway and Individual Sus-ceptibility to Obesity

Author(s): Harry F. Luglio.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
(Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

Volume 16 , Issue 1 , 2016

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Abstract:

Obesity is a worldwide problem that adversely affects human health. Genetic factors have been suggested to play role in the development of obesity. SNPs on proteins involved in de novo lipogenesis had been proposed to affect individual susceptibility for obesogenic environment. De novo lipogenesis is the process of converting carbohydrate absorbed from dietary intake into fat and this process usually occurs after a high carbohydrate intake. In modern society, where foods and beverages with highly processed carbohydrates are getting affordable, understanding the role of genetic factors has become more crucial. In this review, several genes that were previously reported to influence the risk of obesity has been pointed out. This observation was supported by previous findings in animal model which showed that genetic knock-out of genes involved in de novo lipogenesis (FASN and SCD-1) was found to be related to changes in obesity phenotype. Those genes not only produce enzymes which directly convert carbohydrate metabolite into fatty acid, but also influence the production of lipogenic enzymes.

Keywords: de novo lipogenesis, FASN, fat, genetic, obesity, SCD-1, SNP.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2016
Page: [31 - 38]
Pages: 8
DOI: 10.2174/187152221601160413195034
Price: $58

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