Background: Colocasia esculenta is a fast growing plant and is
cultivated for consumption of leaf and tuber. Polysaccharide obtained from
the tubers of Colocasia esculenta is known as Taro polymer. Chemically it is
neutral heteropolysaccharide of galactose, galactose and arabinose.
Objective: The present research work was aimed at the development and
characterization of orally disintegrating tablet of Valsartan using natural
disintegrant to produce rapid onset of action and patient compliance.
Method: Polysaccharide from Colocasia esculenta tubers was isolated using
solvent precipitation method. The isolated polysaccharide was investigated
as disintegrant in orally disintegrating tablets. Valsartan, an antihypertensive drug, was
selected as a model drug. The drug excipient interactions were characterized by FTIR studies.
The tablets of Valsartan were prepared separately using different concentrations [2.5, 5, 7.5
and 10 % w/w] of isolated Colocasia esculenta polysaccharide and Kollidon®, Ac-Di-Sol® as
synthetic superdisintegrants by using direct compression method. The tablets thus prepared
were evaluated for various pre-compression and post-compression parameters. The
disintegration time and in vitro drug release of the optimized formulation was compared with
the available marketed formulation. The stability studies were performed on the optimised
Results: The formulation F12 containing 10 % of polysaccharide showed rapid wetting time
and disintegration time and is comparable to formulations prepared using synthetic
superdisintegrants at the same concentration level.
Conclusion: Colocasia esculenta polysaccharide can be used as a disintegrant in the
formulation of orally disintegrating tablets. Its disintegrating property was found to be
comparable with that of the commercially available superdisintegrants.