Molecular imaging can be used to evaluate the spatial–time change of the
molecular biological phenomenon of the cell–molecule level in living bodies. Molecular imaging technology is expected
to be applied in the fields of drug development, clinical diagnosis, and life science research. Specifically, positron emission
tomography (PET) is a powerful non-invasive imaging technology for investigating physiological parameters in living
animals using compounds labeled with PET radioisotopes as molecular probes. This review summarizes and compares
various 18F-conjugation techniques that employ the chemical and enzymatic reactions of different types of tumor-targeting
biological molecules such as peptides, proteins, antibodies, and nucleic acids.
Keywords: Chemoenzymatic reaction, Chemical reaction, Positron emission tomography (PET) probe, Biologics, Biopharmaceutics,
Fluorine-18 (18F), Peptide, Protein, Oligonucleotide, Antibody, Click chemistry, Tumor targeting.
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