Over the last 30 years, nanoparticle-based medicine has received tremendous attention due to its advances
with smart therapeutics and less toxicity. Few nanomedicine products have been approved for commercial use
in the clinic (such as Doxil®, Ambraxane®...). Nanomedicine research is still at its early stage and the preparation of
nanoparticles must be carefully considered. Systems involving further increased supersaturation, either via solvent
evaporation, temperature reduction or anti-solvent mixture, were suggested to be capable of inducing nanoprecipitation
(NPT). Since this technique is straight-forward, fast and easy to duplicate in practice, it is highly preferred
and recommended. In this review, the process of NTP was described and discussed in detail. Factors that affect
the encapsulation efficiency, the nanoparticle size, the morphology and the stability of nanoparticles prepared
by NTP were described. This process is one of the most preferable processes for preparing solid nano-protein due to their elegant techniques
that preserve the bioactivity of proteins. Although the production of nanoparticles by this process has not been applied in the
pharmaceutical industry due to the organic solvent issue, the production equipment for large-scale has been marketed.
Keywords: Nano-precipitation, anti-solvent, encapsulation efficiency, solid nano-protein, morphology, stability.
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