Combinatorial Dansyl Library and its Applications to pH-Responsive Probes

Author(s): Seong Cheol Hong, Dhiraj P. Murale, Jun-Seok Lee.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 19 , Issue 5 , 2016

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Abstract:

Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.

Keywords: Combinatorial chemistry, dansyl chloride, pH sensor.

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Article Details

VOLUME: 19
ISSUE: 5
Year: 2016
Page: [347 - 352]
Pages: 6
DOI: 10.2174/1386207319666160408150203
Price: $65

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