Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus | BenthamScience

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Author(s): Miha Tibaut, Daniel Petrovič.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 14 , Issue 1 , 2016

Abstract:

The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to influence oxidative stress levels and are therefore thought to impact CAD pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample selection and thus better results in antioxidant trials. In this review, we summarize the evidence of oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants tested in subjects with CAD.

Keywords: Antioxidants, coronary artery disease, diabetes mellitus, insulin, obesity, oxidative stress.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2016
Page: [23 - 38]
Pages: 16
DOI: 10.2174/1871525714666160407143416

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