Causative agents of infectious disease that are multidrug resistant bacterial pathogens
represent a serious public health concern due to the increasingly difficult nature of
achieving efficacious clinical treatments. Of the various acquired and intrinsic antimicrobial
agent resistance determinants, integral-membrane multidrug efflux pumps of the major facilitator superfamily
constitute a major mechanism of bacterial resistance. The major facilitator superfamily (MFS) encompasses
thousands of known related secondary active and passive solute transporters, including multidrug efflux
pumps, from bacteria to humans. This review article addresses recent developments involving the targeting by
various modulators of bacterial multidrug efflux pumps from the major facilitator superfamily. It is currently
of tremendous interest to modulate bacterial multidrug efflux pumps in order to eventually restore the clinical
efficacy of therapeutic agents against recalcitrant bacterial infections. Such MFS multidrug efflux pumps are
good targets for modulation.
Keywords: Antimicrobial agents, bacterial pathogens, drug targets, efflux pump modulation, infection,
major facilitator superfamily, multidrug resistance.
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