Endoplasmic Stress Inhibitors for Homocysteine Induced Cardiovascular Disease

Author(s): Anthony Zulli.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 18 , 2016

Abstract:

Cardiovascular disease (CVD) remains a major cause of death and disability worldwide, thus preventing and inhibiting CVD remains a health priority. Several lines of pharmacological interventions have not met with great success, thus inhibition of novel cellular stress pathways could be a novel therapeutic avenue to treat CVD. This review will focus on homocysteine and endoplasmic reticulum stress linked to mitochondria function, and possible therapeutic avenues for treatment.

Keywords: Endoplasmic reticulum stress, endothelial function, homocysteine, atherosclerosis, taurine, Nox.

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Article Details

VOLUME: 22
ISSUE: 18
Year: 2016
Page: [2704 - 2708]
Pages: 5
DOI: 10.2174/1381612822666160406121342
Price: $58

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