Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome

Author(s): Hitender Sharma, Sunil Kumar*.

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 10 , 2017

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Abstract:

This review covers recent discoveries of phytoconstituents, herbal extracts and some semi-synthetic compounds for treating metabolic syndrome with AMPK activation as one of their mechanisms of action. Recent researches have demonstrated AMPK activation to ameliorate multiple components of metabolic syndrome by regulating a balance between anabolic and catabolic cellular reactions. The review attempts to delineate the AMPK activation by natural agents from the perspective of its functional consequences on enzymes, transcription factors and signaling molecules and also on other potential factors contributing in the amelioration of metabolic syndrome.

Keywords: Cardiovascular disorders, diabetes, obesity, metabolic syndrome, transcription factors, phytoconstituents.

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Article Details

VOLUME: 24
ISSUE: 10
Year: 2017
Page: [1007 - 1047]
Pages: 41
DOI: 10.2174/0929867323666160406120814
Price: $58

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