In-vitro Characterization of Chitosan Nanoparticles of Fluconazole as a Carrier for Sustained Ocular Delivery

Author(s): Kumaraswamy Santhi, Selvadurai Muralidharan, Young H. Yee, Fong Y. Min, Chong Z. Ting, Durga Devi.

Journal Name: Nanoscience & Nanotechnology-Asia

Volume 7 , Issue 1 , 2017

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Abstract:

The aim of the present study is to develop and formulate a nanoparticulate carrier for sustained and ocular delivery of Fluconazole and to study its in-vitro release characters. Chitosan nanoparticles of Fluconazole were formulated by spontaneous emulsification and cross-linking method. The mean particle size, drug loading capacity, invitro release profile and release kinetics were studied. The antifungal efficacies of nanospheres were compared with conventional eye drops by cup-plate method. The average particle size was found to be 152.85±13.7nm. The drug loading capacity of all drug loaded nanoparticles was found to be optimum (≤50%). The in-vitro release study revealed the zero order kinetics and Higuchi’s diffusion mechanism. The drug bound nanoparticles exhibited good in-vitro antifungal effect in comparison with conventional eye drops. The formulated nanoparticles were found to be a suitable carrier for sustained ocular delivery of Fluconazole in terms of optimum drug loading, sustained release characters and antifungal activity.

Keywords: Chitosan, fluconazole, nanoparticles, ocular, sustained release.

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2017
Page: [41 - 50]
Pages: 10
DOI: 10.2174/2210681206666160402003316
Price: $58

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