The aim of the present study is to develop and formulate a nanoparticulate
carrier for sustained and ocular delivery of Fluconazole and to study its in-vitro release
characters. Chitosan nanoparticles of Fluconazole were formulated by spontaneous
emulsification and cross-linking method. The mean particle size, drug loading capacity, invitro
release profile and release kinetics were studied. The antifungal efficacies of
nanospheres were compared with conventional eye drops by cup-plate method. The
average particle size was found to be 152.85±13.7nm. The drug loading capacity of all
drug loaded nanoparticles was found to be optimum (≤50%). The in-vitro release study
revealed the zero order kinetics and Higuchi’s diffusion mechanism. The drug bound
nanoparticles exhibited good in-vitro antifungal effect in comparison with conventional
eye drops. The formulated nanoparticles were found to be a suitable carrier for sustained
ocular delivery of Fluconazole in terms of optimum drug loading, sustained release
characters and antifungal activity.
Keywords: Chitosan, fluconazole, nanoparticles, ocular, sustained release.
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