Lipid nanocapsules (LNCs) were designed more than 15 years ago to deliver lipophilic
drugs to cells with non toxic excipients by mimicking lipoproteins. During the last 5 years these promising
nanocarriers were re-designed to deliver nucleic acids to cancer cells. This short review sums up
the features of LNCs and describes how DNAs or RNAs can be associated or encapsulated in these
lipid carriers. The results of transfection effects on cells in vitro or in vivo are also presented. These
new therapeutic strategies have been mainly proposed for glioma and melanoma treatment because
these cancers are characterized by multiple acquired resistances, which can be reversed by DNA transfection
or siRNA interference as it is discussed in this paper. In conclusion, LNCs are very good candidates to deliver nucleic
acids to cells in the course of anti-cancer therapies.
Keywords: Cancer therapy, DNA, lipid nanocapsules, nanomedicine, non-viral vectors, RNA.
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