Recent Advances in Geriatric Medicine

Volume: 1

Chronic Diseases in Geriatric Patients

Indexed in: EBSCO.

The incidence of multiple chronic diseases affecting a single individual is common among elderly patients. This incidence is believed to be associated with a decline in many health outcomes, ...
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Halting the Decline in Cognition: New Insights into Alzheimer’s Disease

Pp. 73-91 (19)

Kareeann Sok Fun Khow and Tuck Yean Yong

Abstract

Alzheimer’s disease is a major public health concern globally and has been identified as a research priority. Although this disease has been recognized for more than a century, there is an urgent need to improve our understanding of its pathogenesis in order to advance development of disease-modifying treatments. Clinical diagnosis of Alzheimer’s disease remains the main method of identifying the disease but neuroimaging and biomarkers are emerging as adjunct tests in selective cases. Only a few pharmacological treatments are available for Alzheimer’s disease and modest benefits are only observed in the mild-to-moderate disease. Without effective treatment, non-pharmacological approaches and prevention remain important. Nonpharmacological approaches such as exercise, cognitive stimulation therapy and computerized mind games are potentially beneficial in slowing the progression of Alzheimer’s disease. Behavioural and psychological symptoms in Alzheimer’s disease are still challenging to manage and require a combination of non-pharmacological and pharmacological approaches. Several novel therapies are currently under investigation and clinical trials of these agents will reveal if they are beneficial in the treatment of Alzheimer’s disease.

Keywords:

Alzheimer’s disease, Anticholinesterase inhibitors, Behavioural symptoms, Carers, Cognitive impairment, Dementia, Diagnosis, Lifestyle modifications, Memantine, Psychological symptoms, Treatment.

Affiliation:

Aged and Extended Care Services, The Queen Elizabeth Hospital and Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia.