Diels Alder cycloaddition is one of the most valuable reactions in organic chemistry
for the building of cyclic systems. Recent advances in metabolic engineering, computational
methods and chemical biology in general, have allowed designing new artificial enzymes.
Apart from, metal and simple organic catalysts more complex catalytic systems
based on proteins, RNA and DNA fragments have been demonstrated to be active as Diels-
Alderases. This review covers selected advances in the field of artificial enzyme-catalyzed
Diels-Alder reaction in last two decades.
Keywords: Antibody catalysis, de novo computational enzyme design, Diels Alderase, Diels-Alder reaction, DNA catalysis, mechanistic
studies, RNA catalysis.
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