Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis

Author(s): Feng Qian , Feng-Ru Tang .

Journal Name: Current Neuropharmacology

Volume 14 , Issue 5 , 2016

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Abstract:

Neurotransmitter and receptor systems are involved in different neurological and neuropsychological disorders such as Parkinson's disease, depression, Alzheimer’s disease and epilepsy. Recent advances in studies of signal transduction pathways or interacting proteins of neurotransmitter receptor systems suggest that different receptor systems may share the common signal transduction pathways or interacting proteins which may be better therapeutic targets for development of drugs to effectively control brain diseases. In this paper, we reviewed metabotropic glutamate receptors (mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe epilepsy, and proposed some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.

Keywords: Calmodulin, drug target, epileptogenesis, homer, interacting proteins, metabotropic glutamate receptors (mGluRs), protein kinase C (PKC), signal transduction pathways.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2016
Page: [551 - 562]
Pages: 12
DOI: 10.2174/1570159X14666160331142228
Price: $58

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