Current Strategy for Cisplatin Delivery

Author(s): Zhanguo Yue, Zhiqiang Cao.

Journal Name: Current Cancer Drug Targets

Volume 16 , Issue 6 , 2016

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Abstract:

Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations were developed. In this minireview, we summarized the recent progress of cisplatin delivery strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges preventing the development of improved drug formulations were identified, and effective approaches to address these issues were discussed in the context of these recent works.

Keywords: Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2016
Page: [480 - 488]
Pages: 9
DOI: 10.2174/1568009616666160328113006
Price: $58

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