Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings.
However, its serious side effects and its resistance developed by tumor cells hinder its usage. To
decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations
were developed. In this minireview, we summarized the recent progress of cisplatin delivery
strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges
preventing the development of improved drug formulations were identified, and effective approaches
to address these issues were discussed in the context of these recent works.
Keywords: Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy.
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