Globally diabetes mellitus (DM) is swiftly reaching epidemic proportions and impose major health care
and socio-economic challenges that are associated with its complications. DM is considered as the major risk factor
for the development of debilitating micro & macro vascular complications. Clinical studies have revealed that development
of diabetic cardiomyopathy (DCM) in subjects with diabetes can occur both- dependent and independent
of pre-existing increased risk factors such as poor glycemic control, hyperlipidemia, and or hypertension. Therefore, DCM represents
as a major challenge for the clinical community for the prompt diagnosis and devising the treatment paradigm to combat the diabetes induced
cardiac dysfunction. In Chinese traditional medical practice, heart ailments have been coped with herbal extracts. Phytochemicals
bioavailability and pharmacokinetic properties are to yet be established completely in human subjects. However, tremendous progress has
been made to isolate, purify the phytochemicals and characterize their effects on mitigating the development of DCM in pre-clinical
models. Currently there are no approved drugs available for the treatment of DCM. In this review, we have discussed the progress made
in understanding the mechanisms for the phytochemicals cardio-protective actions in the diabetic milieu and their caveats and provide future
perspectives for proposing these agents to serve as prototypes in the development of drugs for the management of DCM.
Keywords: Phytochemicals, diabetes mellitus, diabetic cardiomyopathy, cardiovascular complications, cardiac function, oxidative stress,
inflammation, apoptosis, fibrosis.
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