Biological Rationale for Regular Physical Exercise as an Effective Intervention for the Prevention and Treatment of Depressive Disorders

Author(s): Helios Pareja-Galeano, Sara Mayero, María Perales, Nuria Garatachea, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Enzo Emanuele, Beatriz G. Gálvez, Fabian Sanchis-Gomar, Alejandro Lucia.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 24 , 2016

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Abstract:

Depression is a major medical and social problem. Here we review current body of knowledge on the benefits of exercise as an effective strategy for both the prevention and treatment of this condition. We also analyze the biological pathways involved in such potential benefits, which include changes in neurotrophic factors, oxidative stress and inflammation, telomere length, brain volume and microvessels, neurotransmitters or hormones. We also identify major caveats in this field of research: further studies are needed to identify which are the most appropriate types of exercise interventions (intensity, duration, or frequency) to treat and prevent depression.

Keywords: Major depression, physical activity, neurogenesis, brain-derived neurotrophic factor, serotonin, antidepressant.

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Article Details

VOLUME: 22
ISSUE: 24
Year: 2016
Page: [3764 - 3775]
Pages: 12
DOI: 10.2174/1381612822666160322144537
Price: $58

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