Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis
Pp. 103-160 (58)
Rossella Di Stasi, Lucia De Rosa, Alessandra Romanelli and Luca D. D`Andrea
Angiogenesis regulation strictly depends on the balance between pro- and
anti-angiogenic molecules such as growth factors. Growth factors exert their biological
action selectively binding to and activating specific cell membrane receptors which then
transfer the message to cell interior triggering specific biochemical pathways ending in
the angiogenic response. Molecules able to interfere with the molecular recognition
between an angiogenic growth factor and its receptor can modulate the angiogenesis.
Peptides are good candidates to develop new lead compounds able to target the growth
factor-receptor protein interface for pharmacological applications. In this review we
describe peptides targeting the receptors of the pro-angiogenic growth factors Fibroblast
Growth Factor, Platelet-Derived Growth Factor and Vascular Endothelial Growth
Factor. The biological function and the three-dimensional structure of each growth
factor/receptor system are discussed, as well as the molecular interaction between
peptides and the receptors. Finally, we highlight the pharmacological and diagnostic
applications of these peptides in angiogenesis related diseases.
Angiogenesis, anti-angiogenic, cancer, cysteine knot motif, cytokine,
endothelial cells, FGF, FGFR, Growth factor, molecular imaging, PDGF,
PDGFR, peptide, phage display library, pro-angiogenic, structure-based design,
therapeutic angiogenesis, tyrosine kinase receptor, VEGF, VEGFR.
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy.