Frontiers in Medicinal Chemistry

Volume: 9

Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO., Ulrich's Periodicals

Frontiers in Medicinal Chemistry is an E-book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments ...
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Purinergic Receptors and Pain–An Update

Pp. 3-55 (53)

Geoffrey Burnstock

Abstract

There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the roles played by P2X3, P2Y2/3, P2X4, P2X7 and P2Y12 receptors in neuropathic and inflammatory pain. Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed.

Keywords:

Adenosine, ATP, bladder, cancer, gut, heart, inflammation, joints, lung, mechanosensory transduction, migraine, neuropathic, P1, P2X, P2Y, sensory, skin.

Affiliation:

Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.