The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons

Author(s): J. Shen, W.X. Li, Z.G. Xiao, L. Zhang, M.X. Li, L.F. Li, W. Hu, L. Lu, F. Boudreau, C.H. Cho.

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 11 , 2016

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Abstract:

The arachidonic acid metabolizing enzymes, cyclooxygenase-2 (COX-2) and 5- lipoxygenase (5-LOX), are both highly expressed during the carcinogenesis in colons. Cigarette smoking promotes these carcinogenic processes at the early stage during adenoma formation. In this article, the involvement of COX-2 and 5-LOX, alongside with the dual COX/5-LOX inhibitors in colorectal cancer development is introduced. The co-regulation of 5-LOX and COX-2 in colon cancer growth and its relationship with cigarette smoke and hyaluronic acid-CD44v6 is also described. It is envisaged that dual inhibition of 5-LOX/COX could be the most promising therapeutic option for the treatment of colorectal cancer in humans.

Keywords: 5-LOX, COX-2, cigarette smoke, colon cancer, lincofelone, hyaluronic acid.

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Article Details

VOLUME: 23
ISSUE: 11
Year: 2016
Page: [1131 - 1138]
Pages: 8
DOI: 10.2174/0929867323666160321122431
Price: $58

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