Synthesis, Characterization, and Atenolol Delivery Application of Functionalized Mesoporous Hydroxyapatite Nanoparticles Prepared by Microwave-Assisted Co-precipitation Method

Author(s): Sobhan Mortazavi-Derazkola, Mohammad Reza Naimi-Jamal, Seyedeh Masoumeh Ghoreishi.

Journal Name: Current Drug Delivery

Volume 13 , Issue 7 , 2016

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Background: Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensives. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. A method for slow release of atenolol in intestine is helpful to prevent such side effects.

Methods: A facile co-precipitation microwave-assisted method was used to fabricate mesoporous hydroxyapatite nanoparticles (mHAp). It was then functionalized to have SO3H groups. The synthesized material was used for storage/slow release study of atenolol.

Results: Atenolol loaded mHAp shows immediate release of atenolol in pH 8, whileafter functionalizing shows up to ca. 30% release at the beginning. In pH 1, 50% of drug was released after 10 h from AT@mHAp and after 18h the drug was almost completely released.The drug release profiles of functionalized HAp at pH value 1 and 8reveals the complete release of atenolol in intestine pH, while no complete release is observed in stomach environment.

Conclusion: The aims of this work were synthesis and characterization of mesoporous HAp through the microwave-assisted co-precipitation method and elucidate the underlying drug release capability of mesoporous HAp nanoparticles. The SO3H group was incorporated into the mesoporous HAp and then used as drug delivery carriers using atenolol as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). Increasing pH value to 8 causes increase in the drug release.

Keywords: Atenolol, drug release, mesoporous hydroxyapatite nanoparticles, microwave-assisted co-precipitation, MPTS.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 7
Year: 2016
Page: [1123 - 1129]
Pages: 7
DOI: 10.2174/1567201813666160321115543
Price: $58

Article Metrics

PDF: 16
HTML: 3
PRC: 1