Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives

Author(s): Agata Paneth, Monika Wujec, Tomasz Plech, Edyta Kuśmierz, Dominika Hagel, Szymon Kosiek, Ewa Jagiello-Wójtowicz, Iwona Piątkowska-Chmiel, Mariola Herbet, Magdalena Izdebska, Ewa Kędzierska, Jolanta Orzelska-Górka.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 15 , Issue 6 , 2016

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Abstract:

Two thiosemicarbazide derivatives 1 and 2, three 2-amino-1,3,4-thiadiazole derivatives 3-5, and three N1- substituted-4-methyl-1,2,4-triazole-5-thione derivatives 6-8 were synthesized and evaluated for their central nervous system effects using rodent behavioral models. With the exception of 6, all compounds were devoid of neurotoxicity and they did not affect the body temperature of mice. New lead structures 1-4 with potential analgesic activity were identified.

Keywords: Analgesic activity, pharmacological screening, thiadiazoles, thiosemicarbazides, triazoles.

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Article Details

VOLUME: 15
ISSUE: 6
Year: 2016
Page: [730 - 739]
Pages: 10
DOI: 10.2174/1871527315666160321110818
Price: $58

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