Abstract
Major depressive disorder (MDD) is a debilitating illness that affects a significant percentage of the world population. This disorder is associated with diminshed productivity and reduced quality of life; unfortunately the underlying pathophysiological mechanisms are not fully clarified. Recently, several studies have suggested that psychiatric disorders could be considered as inflammatory disorders; nevertheless.. Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factorsThere is strong evidence that depression involves alterations in multiple aspects of immunity that may contribute to the development or exacerbation of a number of medical disorders and also may play a role in the pathophysiology of depressive symptoms.
This review highlights the role of neuroinflammation and immunity in the pathophysiology of psychiatric disorders such as MDD.
Keywords: Immunity, major depressive disorder, neuroinflammation.
CNS & Neurological Disorders - Drug Targets
Title:Neuroinflammation and Immunity: A New Pharmacological Target in Depression
Volume: 15 Issue: 4
Author(s): Rosalia Crupi and Salvatore Cuzzocrea
Affiliation:
Keywords: Immunity, major depressive disorder, neuroinflammation.
Abstract: Major depressive disorder (MDD) is a debilitating illness that affects a significant percentage of the world population. This disorder is associated with diminshed productivity and reduced quality of life; unfortunately the underlying pathophysiological mechanisms are not fully clarified. Recently, several studies have suggested that psychiatric disorders could be considered as inflammatory disorders; nevertheless.. Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factorsThere is strong evidence that depression involves alterations in multiple aspects of immunity that may contribute to the development or exacerbation of a number of medical disorders and also may play a role in the pathophysiology of depressive symptoms.
This review highlights the role of neuroinflammation and immunity in the pathophysiology of psychiatric disorders such as MDD.
Export Options
About this article
Cite this article as:
Crupi Rosalia and Cuzzocrea Salvatore, Neuroinflammation and Immunity: A New Pharmacological Target in Depression, CNS & Neurological Disorders - Drug Targets 2016; 15 (4) . https://dx.doi.org/10.2174/1871527315666160321105339
DOI https://dx.doi.org/10.2174/1871527315666160321105339 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lifestyle Factors and Endothelial Function
Current Vascular Pharmacology Critical Illness in Obstetric Patients: Introduction and Epidemiology
Current Women`s Health Reviews Static Cerebral Blood Flow Autoregulation in Humans
Current Hypertension Reviews The Use of Nitric Oxide Synthase Inhibitors in Inflammatory Diseases: A Novel Class of Anti-Inflammatory Agents
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Synthesis and Biological Activity of 3-(2, 8, 9-Trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic Acids
Medicinal Chemistry Update on the Medical Treatment of Allergic Rhinitis
Inflammation & Allergy - Drug Targets (Discontinued) Therapeutic Effects and Mechanisms of Action of Cyclosporine A Ophthalmic Solution in the Treatment of Vernal Keratoconjunctivitis
Current Pharmaceutical Analysis Musculoskeletal US: Taking the Management of Psoriatic Arthritis to a New Horizon
Current Rheumatology Reviews Exploiting Protein Phosphatase Inhibitors Based on Cantharidin Analogues for Cancer Drug Discovery
Mini-Reviews in Medicinal Chemistry Recent Advances in the Treatment of Neurogenic Erectile Dysfunction
Recent Patents on CNS Drug Discovery (Discontinued) Family History and Preclinical Atherosclerosis
Current Hypertension Reviews Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature
Current Pharmaceutical Design Statins and Portal Hypertension: A New Pharmacological Challenge
Current Vascular Pharmacology Migraine and Coronary Artery Disease: An Open Study on the Genetic Polymorphism of the 5, 10 Methylenetetrahydrofolate (MTHFR) and Angiotensin I-Converting Enzyme (ACE) Genes
Central Nervous System Agents in Medicinal Chemistry Regulation of Multidrug Resistance by Pro-Inflammatory Cytokines
Current Cancer Drug Targets Cyclosporin A: A Therapeutic Strategy in Allergic Diseases
Letters in Drug Design & Discovery Synthesis and Biological Activity of 3-(2, 8, 9-trioxa-aza-1-germatricyclo [3. 3. 3. 0] undecane-1-yl)-caffeic Acid
Medicinal Chemistry Regulatory Mechanism of the Gastric Hyperemic Response Following Barrier Disruption: Roles of Cyclooxygenase-1, the Prostaglandin E<sub>2</sub>/EP1 Receptor and Sensory Neurons
Current Pharmaceutical Design Biologics for Extraintestinal Manifestations of IBD
Current Drug Targets Beneficial Effects of Statins on Endothelial Dysfunction and Vascular Stiffness
Current Vascular Pharmacology