Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are neurodevelopmental and neurodegenerative
disorders respectively, with devastating effects not only on the individual but also the society. Collectively, a number of
factors contribute to the expression of ASD and AD. It is of utmost curiosity that these disorders express at different
stages of life and there is an involvement of certain susceptible genes. This genetic basis makes the background of
common associations like memory deficits, cognition changes, demyelination, oxidative stress and inflammation, an
integral part of both disorders. Modern technology resulting in genetically modified crops and increase in gadgets emitting
electromagnetic frequencies have resulted in enhanced risks for neurological dysfunctions and disorders like ASD and
AD. Subsequent advances in the psychological, pharmacological, biochemical and nutritional aspects of the disorders
have resulted in the development of newer therapeutic approaches. The common clinical features like language
impairment, executive functions, and motor problems have been discussed along with the patho-physiological changes,
role of DNA methylation, myelin development, and heavy metals in the expression of these disorders. Psychopharmacological
and nutritional approaches towards the reduction and management of risk factors have gained attention
from the researchers in recent years. Current major therapies either target the inflammatory pathways or reduce cellular
oxidative stress. This contribution focuses on the commonalities of the two disorders.
Keywords: Autism, Alzheimer's disease, inflammation, oxidative stress, apraxia, memory deficits, motor dysfunctions.
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