New Insight into 2-Methoxyestradiol- a Possible Physiological Link between Neurodegeneration and Cancer Cell Death

Author(s): Magdalena Gorska, Alicja Kuban-Jankowska, Jaroslaw Slawek, Michal Wozniak.

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 15 , 2016

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Abstract:

The pathways leading to development of neurodegenerative disease and cancer cell death may overlap. Interestingly, the main neurodegeneration-causing factors have been suggested to play a pivotal role in the regulation of tumor growth. Another common component in neurodegenerations and cancer is nitro-oxidative stress. Depending on the environmental conditions, the nitro-oxidative stress may lead to cancerogenesis or cancer cell death. On the other side, it may also result in a variety of neurodegenerative diseases.

Based on the literature data, we suggest that 2-methoxyestradiol may be considered as a physiological link between development of neurodegenerations and cancer cell death. 2-methoxyestradiol is a physiological compound, a metabolite of 17β-estradiol. Interestingly, 2-methoxyestradiol, branded as Panzem, is also considered as a potent anticancer agent, currently investigated in several clinical trials. The review aims on making closer the facts concerning anticancer and plausible neurotoxic activities of 2-methoxyestradiol, which may suggest adverse neurological long-term effects of the drug in cancer patients.

Keywords: Neurodegenerations, cancer, 2-methoxyestradiol, reactive nitrogen species, reactive oxygen species, neuronal nitric oxide synthase.

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Article Details

VOLUME: 23
ISSUE: 15
Year: 2016
Page: [1513 - 1527]
Pages: 15
DOI: 10.2174/0929867323666160316123443
Price: $58

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