Progress in Research of KV1.1 and KV1.3 Channels as Therapeutic Targets

Author(s): Wei Zhao , Yuan Chen .

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 16 , 2016

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Abstract:

Voltage-gated potassium channels (KV) mainly response in action potential repolarization in excitable cells and also participate in regulating resting potentials in non-excitable cells, involved in diverse physiological processes. This review focuses on potential drug developments targeting the KV1.1 and KV1.3 channels. KV1.1 mainly existing in the nervous system plays key roles in controlling neuronal excitability; while the distribution of KV1.3 in different types of cells contributes to a variety of cellular processes. This article seeks to review the distributions of two channels, their roles in diseases, phenotypes of knockout mice, human channelopathies and selective modulators.

Keywords: Autoimmune disease, channel blocker, KV1.1, KV1.3, potassium channel, toxin.

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Article Details

VOLUME: 16
ISSUE: 16
Year: 2016
Page: [1877 - 1885]
Pages: 9
DOI: 10.2174/1568026616666160315142920
Price: $58

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