Atrial fibrillation (AF) is one of the common arrhythmias that threatens human health and brings a huge burden
to society. Current treatments of AF possess limited efficacy and considerable risks, so a lot of efforts have been made to
develop new AF therapies. Kv1.5 potassium channel is considered as an efficacious and safe therapeutic target of AF for
its selective existence in atrium. This review will give a brief profile of Kv1.5 potassium channel and describe the progress
of Kv1.5 inhibitors in this decade from nonselective drugs to selective agents. The final section will discuss the advantages
and disadvantages between selectivity and non-selectivity.
Keywords: Atrial fibrillation; IKur, Kv1.5, Multiple ion channel inhibitor, Nonselective inhibitor, Selective Kv1.5 inhibitor.
Rights & PermissionsPrintExport