Positron emission tomography (PET) neuroimaging of ion channel linked
receptors is a developing area of preclinical and clinical research. The present review
focuses on recent advances with radiochemistry, preclinical and clinical PET imaging
studies of three receptors that are actively pursued in neuropsychiatric drug discovery:
namely the γ-aminobutyric acid-benzodiazapine (GABA) receptor, nicotinic acetylcholine
receptor (nAChR), and N-methyl-D-aspartate (NMDA) receptor. Recent efforts to develop new PET radioligands
for these targets with improved brain uptake, selectivity, stability and pharmacokinetics are highlighted.
Keywords: Positron Emission Tomography, Ion Channel, γ-Aminobutyric Acid-Benzodiazapine Receptor, Nicotinic Acetylcholine
Receptor, N-Methyl-D-Aspartate Receptor.
Rights & PermissionsPrintExport