In order to explain the molecular causes of Parkinson’s Disease (PD) it is important to understand
the effect that mutations described as causative of the disease have at the functional level. In
this special issue, several authors have been reviewing the effects in PD and other parkinsonisms of
mutations described in LRRK2, α-synuclein, PINK1-Parkin-DJ-1, UCHL1, ATP13A2, GBA, VPS35,
FBOX7 and HTRA2. In this review, we compile the knowledge about other proteins with a more
general role in neurodegenerative diseases (MAPT) or for which less data is available due to its recent
discovery (EIF4G1, DNAJC13), the lack of structural or functional data (as for PLA2G6 or
DNAJC6), or even their doubtful association with the disease (as for GIGYF2, SYNJ1 and SPR).
Also the cellular pathways involved in this disease are reviewed, with the goal of having an overview
of the effects on the proteins and its possible role in the disease. This knowledge could also serve as
the basis for designing tools that may potentially be used as a treatment for the disease, such as inhibitory
or activating molecules, as well as other involved in regulating the half-life of the proteins
Keywords: SPR, GIGYF2, PLA2G6, eIF4G1, DNAJC6, SYNJ1, DNAJC13, PARK10, PARK16, MAPT.
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