Frontiers in Inflammation

Basic Biology and Clinical Aspects of Inflammation

Basic Biology and Clinical Aspects of Inflammation provides information about the critical cells and biochemical mediators involved in the complex process of inflammation. Readers are introduced to ...
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Inflammation in Type 2 Diabetes

Pp. 164-179 (16)

Agbor Ndip, Edward B. Jude and Andrew J.M. Boulton

Abstract

Accumulating evidence has demonstrated that intensive glucose control improves microvascular complications in type 2 diabetes; however, such interventions have limited value in reducing macrovascular outcomes. Diabetes is in fact a heterogeneous disorder, with subclinical inflammation playing a significant role. An overview of the key inflammatory mediators and signalling pathways driving the onset of diabetes (beta cell failure and insulin resistance) and the development of complications is presented in this chapter. The inflammatory pathways involving interleukins (IL-1β and IL-6), tumour necrosis factor (TNF-α), AGE/RAGE and NLRP3 inflammasome all play important and different roles. Further careful characterisation of these pathways is warranted in order to inform novel lines of therapeutic interventions to reduce the burden of disease. As diabetes affects various target organs, topics covered elsewhere in this book have been deliberately omitted, but the reader is encouraged to read those chapters to gain a more comprehensive picture.

Keywords:

Diabetes, IL-1β, IL-6, Inflammasome, Inflammation, Interleukins, NLRP3, TNF-α.

Affiliation:

Warrington General Hospital, Lovely Lane, Warrington, WA5 1QG, UK.