Introduction to Basic Biology and Clinical Aspects of Inflammation
Pp. 3-10 (8)
Roger M. Loria and Robert F. Diegelmann
Abstract: Inflammation has been recognized as biological phenomena for
more than 2000 years by the Roman physician Aulus Cornelius Celcus who described
the four cardinal signs of inflammation heat (calor), redness (rubor), pain (dolour), and
swelling (tumour), a fifth sign, the loss of function was added later . Consequently,
there is ample literature on this subject as illustrated by the fact that more than 500,000
publications on this subject are listed in PubMed. Nevertheless, this volume provides
new relevant information on the topic of inflammation, demonstrating that we have not
yet complete knowledge on this subject. The reader is directed to extensive
introduction of the subject of inflammation  as well as many other reports which
deals with this subject [3 - 10]. This introductory chapter provides a brief summary of
the individual chapter contain in this book.
Acute and Chronic Inflammation, Systemic Inflammatory Response
Syndrome (SIRS), Cell and Biochemical Mediators, Wound Healing, Metabolism
and Aging, Allergy, Diabetes, Cardiovascular, Arthritis, Oral and Gastrointestinal,
Neuroinflammation, Pharmacotherapy, Math Modeling and Network Analysis.
Department of Microbiology and Immunology, PO Box 980678, Virginia Commonwealth University, Richmond, VA 23298-0678, USA.