Analgesic Effects Mediated by Muscarinic Receptors: Mechanisms and Pharmacological Approaches

Author(s): Federica De Angelis, Ada Maria Tata.

Journal Name: Central Nervous System Agents in Medicinal Chemistry

Volume 16 , Issue 3 , 2016

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Abstract:

Chronic pain represents a research field on great clinical relevance and social impactful. It is associated to a variety of pathological events causing un altered excitability of peripheral nerves derived by tissue damage depending on physical, biological and chemical injury. In the last years much attention has been paid in the identification of novel molecules involved in mediating pain sensation useful as therapeutic tools for the development of new analgesic drugs. Muscarinic receptors are widely distributed both in the central and peripheral nervous system. It is known that muscarinic agonists cause analgesic effects via spinal and supraspinal mechanisms. Considering that the analgesia induced by cholinergic agonists is comparable to that observed with morphine, the identification of receptor subtypes involved and the identification of the muscarinic ligands capable of selectively activate these receptors, is of considerable interest for potential therapeutic application. In the present review we describe the role of muscarinic receptors in mediating central and peripheral pain and the mechanisms downstream these receptors responsible of the modulation of nociceptive stimuli. Moreover the therapeutic perspectives and the identification of potential drugs binding muscarinic receptors involved in pain modulation will also be discussed.

Keywords: Acetylcholine, analgesia, bitopic ligands, muscarinic receptors, nociception, VR-1 channel.

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Article Details

VOLUME: 16
ISSUE: 3
Year: 2016
Page: [218 - 226]
Pages: 9
DOI: 10.2174/1871524916666160302103033
Price: $58

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