Tumor Necrosis Factor-α, a Regulator and Therapeutic Agent on Breast Cancer

Author(s): Dongwu Liu, Xiaoqian Wang, Zhiwei Chen.

Journal Name: Current Pharmaceutical Biotechnology

Volume 17 , Issue 6 , 2016

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Abstract:

The cell-mediated immunity and cytotoxic agents play a significant role on tumor cell apoptosis. Tumor necrosis factor-α (TNF-α) is an intricate linker between inflammation and cancer through mediating the process of apoptosis and cell-mediated immunity. A variety of evidences have confirmed the critical role of TNF-α on tumor migration, proliferation, matrix degradation, tumor metastasis, invasion, and angiogenesis. Through binding to receptors, TNF-α participates in activating multiple cell signaling cascades that link inflammation, survival and evolution towards breast cancer. TNF-α is an important agent for tumor biotherapy, but its clinical application is limited for its severe fatal systemic toxicity. The poly-lactic acid microspheres (PLAM) with intratumoral cytokine release hold tremendous potential for the immunotherapy of breast cancer, and TNF-α antagonists may offer therapeutic potential in solid tumors. In addition, TNF-α is related with the blockage of estrogen and progesterone receptors. For breast cancer treatment, it is necessary to understand the molecular signaling pathways that mediate TNF-α and the aggressive behavior of negative breast cancer. The aim of present review is to summarize the effect of TNF-α on breast cancer cells.

Keywords: TNF-α, breast cancer, signal pathway, tumor biotherapy, estrogen, tumor proliferation.

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2016
Page: [486 - 494]
Pages: 9
DOI: 10.2174/1389201017666160301102713
Price: $58

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