Molecular Mechanisms Underlying Psychological Stress and Cancer

Author(s): Kyeong Jin Shin, Yu Jin Lee, Yong Ryoul Yang, Seorim Park, Pann-Ghill Suh, Matilde Yung Follo, Lucio Cocco, Sung Ho Ryu.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 16 , 2016

Become EABM
Become Reviewer

Abstract:

Psychological stress is an emotion experienced when people are under mental pressure or encounter unexpected problems. Extreme or repetitive stress increases the risk of developing human disease, including cardiovascular disease (CVD), immune diseases, mental disorders, and cancer. Several studies have shown an association between psychological stress and cancer growth and metastasis in animal models and case studies of cancer patients. Stress induces the secretion of stress-related mediators, such as catecholamine, cortisol, and oxytocin, via the activation of the hypothalamic-pituitary-adrenocortical (HPA) axis or the sympathetic nervous system (SNS). These stress-related hormones and neurotransmitters adversely affect stress-induced tumor progression and cancer therapy. Catecholamine is the primary factor that influences tumor progression. It can regulate diverse cellular signaling pathways through adrenergic receptors (ADRs), which are expressed by several types of cancer cells. Activated ADRs enhance the proliferation and invasion abilities of cancer cells, alter cell activity in the tumor microenvironment, and regulate the interaction between cancer and its microenvironment to promote tumor progression. Additionally, other stress mediators, such as glucocorticoids and oxytocin, and their cognate receptors are involved in stress-induced cancer growth and metastasis. Here, we will review how each receptor-mediated signal cascade contributes to tumor initiation and progression and discuss how we can use these molecular mechanisms for cancer therapy.

Keywords: Psychological stress, cancer, tumor microenvironment, adrenergic receptor, catecholamine, anticancer drug.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 22
ISSUE: 16
Year: 2016
Page: [2389 - 2402]
Pages: 14
DOI: 10.2174/1381612822666160226144025
Price: $65

Article Metrics

PDF: 97
HTML: 17
EPUB: 2
PRC: 1