In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives
were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT
assay was carried out to determine the cytotoxic effects of the compounds on NIH/3T3 mouse embryonic
fibroblast cell line. Among these compounds, 2-[2-[1-(4-(piperidin-1-yl)phenyl)ethylidene]
hydrazinyl]-4-(4-fluorophenyl)thiazole (7) exhibited notable antimicrobial activity against
Enterococcus faecalis (ATCC 51922), Pseudomonas aeruginosa, Escherichia coli (ATCC 35218),
Candida krusei, Candida glabrata and Candida parapsilosis. Due to its promising antimicrobial activity,
the mutagenic potential of compound 7 was also evaluated by means of Ames test. According
to MTT and AMES assays, this compound was identified as non-toxic and non-mutagenic.
Keywords: Thiazole, hydrazone, piperidine, antimicrobial activity, cytotoxicity, genotoxicity.
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