Abstract
In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT assay was carried out to determine the cytotoxic effects of the compounds on NIH/3T3 mouse embryonic fibroblast cell line. Among these compounds, 2-[2-[1-(4-(piperidin-1-yl)phenyl)ethylidene] hydrazinyl]-4-(4-fluorophenyl)thiazole (7) exhibited notable antimicrobial activity against Enterococcus faecalis (ATCC 51922), Pseudomonas aeruginosa, Escherichia coli (ATCC 35218), Candida krusei, Candida glabrata and Candida parapsilosis. Due to its promising antimicrobial activity, the mutagenic potential of compound 7 was also evaluated by means of Ames test. According to MTT and AMES assays, this compound was identified as non-toxic and non-mutagenic.
Keywords: Thiazole, hydrazone, piperidine, antimicrobial activity, cytotoxicity, genotoxicity.
Letters in Drug Design & Discovery
Title:Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents
Volume: 13 Issue: 9
Author(s): Mehlika Dilek Altıntop, Ahmet Özdemir, Özlem Atlı, Zerrin Cantürk, Merve Baysal and Zafer Asım Kaplancıklı
Affiliation:
Keywords: Thiazole, hydrazone, piperidine, antimicrobial activity, cytotoxicity, genotoxicity.
Abstract: In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT assay was carried out to determine the cytotoxic effects of the compounds on NIH/3T3 mouse embryonic fibroblast cell line. Among these compounds, 2-[2-[1-(4-(piperidin-1-yl)phenyl)ethylidene] hydrazinyl]-4-(4-fluorophenyl)thiazole (7) exhibited notable antimicrobial activity against Enterococcus faecalis (ATCC 51922), Pseudomonas aeruginosa, Escherichia coli (ATCC 35218), Candida krusei, Candida glabrata and Candida parapsilosis. Due to its promising antimicrobial activity, the mutagenic potential of compound 7 was also evaluated by means of Ames test. According to MTT and AMES assays, this compound was identified as non-toxic and non-mutagenic.
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Altıntop Dilek Mehlika, Özdemir Ahmet, Atlı Özlem, Cantürk Zerrin, Baysal Merve and Kaplancıklı Asım Zafer, Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents, Letters in Drug Design & Discovery 2016; 13 (9) . https://dx.doi.org/10.2174/1570180813666160226001021
DOI https://dx.doi.org/10.2174/1570180813666160226001021 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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