Title:The Recent Progress in the Preparation of Chitosan 6-OH Immobilized Cyclodextrin and its Application
VOLUME: 13 ISSUE: 2
Author(s):Yu Chen, Ganlin Song, Yihui Qiu, Huimin Tan, Yanchun Ye and Yanwen Guo
Affiliation:School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, P.R. China.
Keywords:Application, chitosan, cyclodextrin, immobilization, locating, preparation.
Abstract:Chitosan is an ideal biomaterial due to its excellent comprehensive properties. Cyclodextrins
bearing the cavity structure and amphiphilic properties have become the focus of supramolecular
chemistry. The chemical immobilization of cyclodextrin on the chitosan skeleton can be a feasible
means to generate supramolecular host material. However, cyclodextrin is usually immobilized on the
2-NH2 group of chitosan, which suppresses the activities of the amino group such as physiological activities,
functionalization, modification, and so on. Therefore, efforts have been made to immobilize
cyclodextrin at the 6-OH position of chitosan to maintain the functions of the 2-NH2 group, and thus to
achieve materials with the excellent supramolecular inclusion properties of cyclodextrin and the remarkable advantages of
chitosan in membrane formation, immobilization, functionalization and biochemical properties, especially the prominent
bioactivity derived from its 2-NH2. In the present paper, various recently reported synthesis routes for chitosan 6-OH immobilized
cyclodextrin derivatives (CTS-6-CD) were introduced in detail. The applications of CTS-6-CD in drug delivery,
absorbents, the corrosion inhibition of metal and biosensor due to the unique properties of CTS-6-CD was reviewed.
The perspectives on the developing of particular derivatives were also discussed.
