Multi-Target Drugs for Neglected Diseases

Author(s): Luciana Scotti, Francisco J.B.M. Filho, Ricardo O. de Moura, Frederico F. Ribeiro, Hamilton Ishiki, Marcelo S. da Silva, José M.B. Filho, Marcus T. Scotti.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 21 , 2016

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Abstract:

Background: Diseases perceived as neglected tropical infections are generally caused by parasites which reach poor, underserved populations (primarily infrastructure), cause serious damage to health, and many deaths. AIDS and tuberculosis, (although not classified as neglected by WHO), are discriminated against infections which cause great social damage. The drugs currently used to treat these diseases do not have the desired effectiveness, enable the emergence of resistant strains, and in most cases are difficult to obtain. Few pharmaceutical companies are investing in new drug research for neglected diseases, for lack of financial return. This review reports the major neglected diseases, AIDS, tuberculosis, their targets, and research on multi-target drugs. Methods: The studies for new drugs against these infections involve in silico methods, synthesis, structural determinations, analytical analysis and other experimental assays. Results: A new single compound, forecasting possible pharmacodynamic and pharmacokinetic interactions becomes a simpler process; it is also believed that these drugs are safer and more efficient, since they act with synergism on different targets. It occurs but the emergence of new resistant strains and side effects. Conclusion: Multi-target drugs represent a new alternative to find new lead compounds. A ligand that targets two or more receivers may be seen as a potential drug, combating infection by different routes.

Keywords: Chagas disease, African trypanosomosis Human, leishmaniasis, dengue, malaria, AIDS, tuberculosis, multitarget drugs.

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Article Details

VOLUME: 22
ISSUE: 21
Year: 2016
Page: [3135 - 3163]
Pages: 29
DOI: 10.2174/1381612822666160224142552
Price: $58

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